The laboratory of Dr Pawel Grzechnik at the University of Birmingham is looking for a skilled Post-Doctoral Research Associate with experience in RNA biology and molecular biology in order to understand how non-coding RNAs regulate gene expression in differentiating human cells. In particular, the researcher will investigate how small nucleolar/long-noncoding RNA hybrids (sno-lncRNA and SPA lncRNA) control gene expression in induced pluripotent stem cells (iPSC) and will translate this knowledge to uncover molecular basics of Prader-Willi syndrome (PWS).
The researcher will employ cutting-edge sequencing and molecular biology approaches to characterise the transcriptome of iPSCs lacking individual ncRNA from the PWS locus.
This post offers an exciting opportunity for a talented cell and molecular biologist to investigate mechanisms of gene expression and RNA biology using cutting-edge RNA sequencing and cell biology approaches. The successful applicant will also have the opportunity to work at a collaborator’s lab at the Institute of Cancer and Genomic Science, University of Birmingham to develop skills in stem cell biology.
- Work within specified research grants and projects;
- Analyse and interpret research findings and results;
- Contribute to generating funding; and
- Contribute to licensing or spin out deals with demonstrated commercial cusses (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar.
Main Duties and Responsibilities
- Develop research objectives and proposals for own or joint research, with assistance of a mentor if required;
- Contribute to writing bids for research funding;
- Analyse and interpret data;
- Apply knowledge in a way which develops new intellectual understanding;
- Disseminate research findings for publication, research seminars etc.;
- Supervise students on research related work and provide guidance on PhD students where appropriate to the discipline;
- Contribute to developing new models, techniques and methods;
- Undertake management/administration arising from research; and
- Deal with the problems that may affect the achievement of research objectives and deadlines.
Knowledge, Skills, Qualifications and Experience Required
- High level analytical capability;
- The post-holder will hold or be near completing a PhD in a relevant field, with practical experience in molecular biology;
- Ability to communicate complex information clearly;
- Fluency in relevant models, techniques or methods and ability to contribute to developing new ones;
- Ability to assess resource requirements and use resources affectively;
- Understanding of and ability to contribute to broader management/administration processes;
- Contribute to the planning and organising of the research programme and/or specific research project;
- Co-ordinate own work with other to avoid conflict of duplication of effort; and
- Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly.
We value diversity at The University of Birmingham and welcome applications from all sections of the community’