Are you an ambitious researcher looking for your next challenge?
Do you have an established background in ion channel research?
Do you want to further your career in one of the UKs leading research-intensive Universities?
We are researching pharmacological treatments for KCNT1-associated childhood epileptic disorders, for which there is presently no effective therapy. KCNT1 mutations cause an increase in KNa1.1 potassium channel activity and we have used protein structure-based virtual screening to identify novel potassium channel inhibitors. The research builds on our previous work in this area (see Cole et al. 2020, iScience) and aims to identify candidate molecules for further development as a drug. We are looking for a candidate with experience in ion channel function or pharmacology who would like to apply their expertise in the discovery of potential treatments for a rare neurological disorder.
The role, funded by Action Medical Research, will involve pharmacological characterisation of KNa1.1-inhibiting molecules using fluorescence microplate reader assays, manual and automated patch clamp electrophysiology.
The successful candidate will play a key role in advancing our understanding of how compounds inhibit potassium channels and which chemical properties determine their potency and selectivity. Our interdisciplinary project team includes Dr Jonathan Lippiat (ion channel biology), Dr Katie Simmons (medicinal chemistry), and Dr Stephen Muench (structural biology).
You should have a PhD (or close to completion) in ion channel research or a closely allied discipline with experience in patch clamp electrophysiology and mammalian cell culture.