Postdoctoral Position in Chromatin remodeling during breast development and cancer

University of Basel

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Position type:

Full time

23 Oct 2017
22 Nov 2017

Full details:

Reference number: UOB-a466

A postdoctoral position is available in the laboratory of Professor Momo Bentires-Alj at the Department of Biomedicine (DBM) in Basel, Switzerland. Our lab focuses on the molecular mechanisms controlling normal and neoplastic breast stem cells, metastasis and resistance to therapy, and on personalized cancer treatments:

Selected publications of our lab include: 1- Hippo kinases LATS1/2 control human breast cell fate via crosstalk with ERα. Britschgi A, et al., Nature 2017. 2- PIK3CAH1047R induces multipotency and multi-lineage mammary tumors. Koren S, et al., Nature 2015. 3- Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Bonapace L, et al., Nature 2014


Your position

The tasks include studies on transcriptomic and epigenetic (Histone modifications, DNA methylation...) changes in the normal and neoplastic breast. The candidate will work on an interdisciplinary project that uses pathophysiologically relevant models and state-of-the-art technologies to identify molecular mechanisms underlying crosstalk between key signalling pathways and chromatin remodeling in the normal and neoplastic breast.


Your profile

A strong background in gene regulation and epigenetics (Chip-Seq, Atac-Seq, RNA-Seq...) is required. The successful candidate should be highly motivated, have a PhD in epigenetics, and a strong interest in molecular and cellular mechanisms of development and cancer progression.


We offer you

A stimulating, challenging and interdisciplinary research environment, state-of-the-art technologies and core facilities, and attractive employment conditions. The DBM is an international institute pursuing basic, translational and clinical research, with access to cutting-edge core facilities.


Application / Contact

Applications should be submitted electronically at:

Application deadline: applications will be reviewed as they arrive.

Contact: Professor Momo Bentires-Alj:

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